{
  "citation": "Specimen Registry v0.0.7 (2026). Maintained by Michael Gonzalez with AI assistance. https://specimenregistry.org. Data licensed under CC BY 4.0.",
  "license": "https://specimenregistry.org/license",
  "version": "0.0.12-neon",
  "publication": {
    "id": "10.1126/science.1224344",
    "title": "A High-Coverage Genome Sequence from an Archaic Denisovan Individual",
    "authors": [
      "Meyer, M.",
      "Kircher, M.",
      "Gansauge, M.-T.",
      "Li, H.",
      "Racimo, F.",
      "Mallick, S.",
      "Schraiber, J.G.",
      "Jay, F.",
      "Prüfer, K.",
      "de Filippo, C.",
      "Sudmant, P.H.",
      "Alkan, C.",
      "Fu, Q.",
      "Do, R.",
      "Rohland, N.",
      "Tandon, A.",
      "Siebauer, M.",
      "Green, R.E.",
      "Bryc, K.",
      "Briggs, A.W.",
      "Stenzel, U.",
      "Dabney, J.",
      "Shendure, J.",
      "Kitzman, J.",
      "Hammer, M.F.",
      "Shunkov, M.V.",
      "Derevianko, A.P.",
      "Patterson, N.",
      "Andrés, A.M.",
      "Eichler, E.E.",
      "Slatkin, M.",
      "Reich, D.",
      "Kelso, J.",
      "Pääbo, S."
    ],
    "year": 2012,
    "journal": "Science",
    "volume": "338",
    "issue": "6104",
    "pages": "222-226",
    "publication_date": "2012-10-12T00:00:00.000Z",
    "open_access_url": "https://www.science.org/doi/10.1126/science.1224344",
    "pmc_id": null,
    "pubmed_id": null,
    "abstract": "The Denisovans were archaic humans closely related to Neandertals, whose populations overlapped with the ancestors of modern-day humans. Using a single-stranded library preparation method, Meyer et al. (p. 222, published online 30 August) provide a detailed analysis of a high-quality Denisovan genome. The genomic sequence provides evidence for very low rates of heterozygosity in the Denisova, probably not because of recent inbreeding, but instead because of a small population size. The genome sequence also illuminates the relationships between humans and archaics, including Neandertals, and establishes a catalog of genetic changes within the human lineage.",
    "crossref_verified_at": null,
    "verification_state": "draft",
    "verification_notes": "Migrated from ingest file: T1.2_Meyer_2012.md",
    "fts_tsv": "'222':44B '30':47B 'a.m':171C 'a.p':167C 'a.w':153C 'al':42B 'alkan':136C 'also':91B 'analysi':52B 'ancestor':26B 'andré':170C 'archaic':9A,15B,98B 'august':48B 'brigg':152C 'bryc':150C 'c':133C,137C 'catalog':104B 'chang':107B 'close':17B 'coverag':4A 'd':177C 'dabney':156C 'day':30B 'de':131C 'denisova':73B 'denisovan':10A,13B,58B 'derevianko':166C 'detail':51B 'e.e':173C 'eichler':172C 'establish':102B 'et':41B 'evid':64B 'f':122C,128C 'filippo':132C 'fu':138C 'gansaug':116C 'genet':106B 'genom':5A,59B,61B,89B 'green':148C 'h':120C 'hammer':162C 'heterozygos':70B 'high':3A,56B 'high-coverag':2A 'high-qual':55B 'human':16B,31B,96B,110B 'illumin':92B 'inbreed':79B 'includ':99B 'individu':11A 'instead':81B 'j':157C,159C,161C,179C 'j.g':126C 'jay':127C 'k':130C,151C 'kelso':178C 'kircher':114C 'kitzman':160C 'li':119C 'librari':37B 'lineag':111B 'low':67B 'm':113C,115C,117C,147C,175C 'm.f':163C 'm.v':165C 'mallick':123C 'method':39B 'meyer':40B,112C 'modern':29B 'modern-day':28B 'n':143C,169C 'neandert':20B,100B 'onlin':46B 'overlap':23B 'p':43B 'p.h':135C 'patterson':168C 'popul':22B,86B 'prepar':38B 'probabl':74B 'provid':49B,63B 'prüfer':129C 'publish':45B 'pääbo':180C 'q':139C 'qualiti':57B 'r':141C 'r.e':149C 'racimo':121C 'rate':68B 'recent':78B 'reich':176C 'relat':18B 'relationship':94B 'rohland':142C 'schraiber':125C 'sequenc':6A,62B,90B 'shendur':158C 'shunkov':164C 'siebauer':146C 'singl':35B 'single-strand':34B 'size':87B 'slatkin':174C 'small':85B 'stenzel':154C 'strand':36B 'sudmant':134C 'tandon':144C 'u':155C 'use':32B 'whose':21B 'within':108B",
    "created_at": "2026-07-26T18:01:51.160Z",
    "updated_at": "2026-07-27T02:16:42.538Z",
    "study_type": null
  },
  "specimens": [],
  "analyses": [
    {
      "id": "c8507c6a-e1a6-4b6c-a66e-de412a1ea18c",
      "specimen_id": "denisova-3",
      "method": "aDNA-nuclear",
      "dating_method": null,
      "lab": "Max Planck Institute for Evolutionary Anthropology, Leipzig",
      "result_summary": "Established the reference Denisovan genome at ~30× coverage using single-strand library method. Enabled all subsequent Denisovan population-genetic inference.",
      "verification_state": "draft"
    }
  ]
}